To artist: go with what you think makes the best layout.
Panel 1: Taskmaster, Mysterio, El Toro Rojo, and Silencer are sitting at a table in the middle of a crowded Bar With No Name. A bottle of Bucky Beer is in Taskmaster's hand, and El Toro Rojo has a large bottle of Grey Goose. The bar is emphatically not bumpin', and absolutely cannot be said to be thumpin'. Mysterio is clearly nudging Taskmaster, and Silencer is leaning towards Taskmaster.
El Toro Rojo: MAAAAAAAN, THIS BAR IS LAME.
Mysterio: IF ONLY SOMEONE WERE AROUND TO LIVEN UP THE PROCEEDINGS.
Inset panel: Taskmaster looks like he's pretending to be very put upon to be asked, but still begrudgingly aquiescing. Maybe he's rolling his eyes.
Taskmaster: ALRIIIIIIIIIIIIIIIIIIIIIIIIIGHT. I GUEEEEEEEEEEEEESS I'LL TRY SOME STUFF.
Panel 2: Taskmaster is walking across a stage, his progress shown by ghosted images of Spider-man and himself alternating He has a mic and is clearly drunk, but not crazy so. The one connected to the third balloon should be looking directly at the viewpoint.
Taskmaster: OOH, LOOK AT ME I'M SPIDER-MAN, I THINK I'M SO FUNNY. HEY PASTE-BOY, EASY ON THE WHITE STUFF, THIS SUIT'S TAILORED! OH MAN, LOOK AT ME SWING AROUND AND PUNCH FURRIES, I'M SO RAD.
Taskmaster: ON THE SIDE I GET SOME FROM A SEXY CAT BURGLAR AND I STILL WHINE ABOUT HOW I CAN'T GET PLAY, MAYBE BECAUSE I SOLD THE DEVIL MY MARRAIGE TO MY HOT WIFE SO MY OLD-ASS GRANDMOTHER WOULDN'T DIE OF A FRIGGIN' GUNSHOT WOUND.
Taskmaster(this is the one where he's looking at the viewpoint): YEAH, I SAID IT. WHATCHA GONNA DO, DORK-BOY?
Taskmaster: YOU KNOW HOW MANY TIMES I'VE BEEN GUNSHOT WOUNDED? I DON'T, BECAUSE I GET GUNSHOT WOUNDED ALL THE DAMN TIME! IT'S ALMOST PART OF MY BALANCED BREAKFAST AT THIS POINT.
Panel 3: Taskmaster is doing one-handed vertical pushups while beer-bonging. An image of Captain America is ghosted clearly next to him to show who he's taking the skills from. The supervillains in the bar look on.
Many of the supervillains in the crowd: CHUG! CHUG! CHUG! CHUG!
Panel 4: Taskmaster is cutting it up on the wheels of steel, and is fully domed on the sauce by this point, bubbles, swaying, and all. At least 2 DJs are ghosted with him. The crowd is hyped and Mysterio has a mic and has opened his fishbowl as a fog machine
SFX: DEEJAYING NOISES(not what I actually want in there, maybe some music notes and scritchy-scratch noises, go with what you go with)
YEAH YEAH YEAH!
AND YOU DON'T STOP!
TASKMASTER, HE DON'T STOP!
HE PROBABLY WON'T STOP!
I'D LIKE TO KNOW IF HE CAN STOP!
HE GOES ON!
Mysterio: LIKE A MARATHON!
By the way, when this goes up, it'll be 2 days away from my birthday. In Australian time, that is.